Hair Filler: Comprehensive Capillary Rejuvenation

Hair Filler with bioactive peptides is a minimally invasive treatment for hair rejuvenation to increase the density and thickness of hair, available at Institute Medical Laser in Madrid.

Hair cell and scalp revitalization

Hair Filler is a capillary rejuvenation treatment that increases hair density and thickness

What is Hair Filler with bioactive peptides?

Hair Filler is a preparation composed of hyaluronic acid and 7 types of biomimetic peptides that infiltrate the scalp with a triple objective:

  1. Increase hair thickness.
  2. Increase capillary density.
  3. Reactivate hair follicles.

What are the indications of Hair Filler?

Hair Filler treatment indications are:

  • Alopecia:
    • Androgenic alopecia.
    • Female diffuse pattern alopecia.
    • Telogen effluvium.
    • Alopecia in systemic diseases.
    • Alopecia caused by medication.
    • Hereditary syndromes.
  • Combination with other anti-hair loss treatments.
  • Patients who want to increase the speed of hair growth.
  • Men and women with excessive hair loss.
  • Patients with very thin and weak hair.
  • Patients who undergo a hair transplant, to improve the survival rate of the graft.
  • Patients of any age with hair loss or hair growth problems.

types of alopecia

The indications of Hair Filler include, among others, different types of alopecia

What are bioactive peptides or biopeptides?

Bioactive peptides or biopeptides are molecules composed of a sequence of amino acids linked by peptide bonds which play an important role in the physiological processes of the organism. They are regulated by proteolytic control and serve as biomarkers for specific diagnosis and for therapeutics.

Bioactive peptides can be classified as:

  • Peptide hormones.
  • Neuropeptides.
  • Cytokines.
  • Growth Factors.

Peptides that act as growth factors influence the expression of certain genes that, in turn, synthesize different proteins, which is accompanied by important structural improvements in the organism.

The IML capillary preparation contains the peptides which act as growth factors. They are multifunctional peptides that stimulate the hair follicle cells on 3 levels:

  • Differentiation: Pluripotent stem cells located in the dermal papilla.
  • Proliferation: Activation of the expression of the genes responsible for the formation and multiplication of new cells and proteins of the hair shaft.
  • Protein synthesis: Activation of the growth phase or terminal hair anagen phase.

Types of peptides

Peptides that act as growth factors can be of two types:

  1. Signal peptides: Binding to cell membrane receptors, they transmit the signal from the outside to the interior of cells, activating or inhibiting their activity.
  2. Expression or gene silencing peptides: Silencing certain genes and activating others can revitalize the hair follicle and all its components.

The bioactive peptides act as growth factors to stimulate the hair follicle

The bioactive peptides act as growth factors to stimulate the hair follicle

Biopeptide Hair Filler: Comprehensive Capillary Rejuvenation treatment

The Hair Filler applied by IML in alopecia treatments is a latest generation biopeptide compound formulated with hyaluronic acid.

This injectable is designed to revitalize the follicular cells. The 7 biopeptides comprising Hair Filler influence all the components related to the quality and quantity of hair. These molecules act as growth factors, activating protein signalling pathways and the expression of the genes responsible for the hair revitalization.

Hair Filler acts on the following structures:

  • Microcapillaries.
  • Melanin.
  • Keratin.
  • Hair shaft.
  • Follicular bulb and dermal papilla cells.

Benefits of comprehensive capillary rejuvenation treatment

Hair Filler obtains the following benefits:

  • Revitalization of hair follicles and scalp.
  • Activation of hair growth.
  • Inhibition of the hair loss.

How is Hair Filler applied?

Application of Hair Filler treatment should only be conducted by physicians who have received specific training for this injectable.

Under strict aseptic conditions are micro punctures are performed with a 30G needle. The preparation infiltrates through the linear technique to the whole area of the scalp which is being treated.

The micro punctures are performed every 0.2 or 0.3 cm horizontally and every 1 cm vertically.

The amount of product infiltrated for each point is between 0.02 and 0.05 ml.

Once infiltrated, the IML physician performs a gentle massage on the treated area to optimise the homogeneous distribution of the product.

At IML, the average number of sessions of Hair Filler is usually 4, although this number varies according to the needs and goals of each patient. A resting period of a fortnight is required between sessions.

Our physicians recommend applying a monthly maintenance session during the 4 months following treatment.

Hair Filler is compatible with other hair therapies, such as Rigenera stem cell bio-stimulator treatment, growth factors or conventional hair mesotherapy.

micro punctures on the scalp

Infiltration of the Hair Filler is performed via micro punctures on the scalp

What types of biopeptides does Hair Filler contain and how does each work?

The 7 types of Hair Filler biopeptides are:

  1. CG-Keramin2.
  2. Prohairin-ß4.
  3. CG-Seperin.
  4. CG-WINT.
  5. CG-Rehairin.
  6. CG-Nokkin.
  7. CG-Edrin.

Each type or group of biopeptides acts differently in hair rejuvenation:

  1. Revitalising the hair bulb via the dermal papilla and the extracellular matrix.
  2. Acting on the hair growth cycle.
  3. Inhibiting hair loss.
  4. Elasticity and hydration.

1. Revitalising the hair bulb via the dermal papilla and the extracellular matrix

a) Decapeptide-28

Acts on the signalling pathways of pluripotent stem cells on the follicular matrix protein. Stimulates dermal papilla, releasing growth factors to the extracellular matrix to start the cycle of follicular growth.

b) Decapeptide-18

Acts on the protein signalling pathway that influences activation of the follicular cells of the dermal papilla, producing an elongation of the anagen follicular growth stage, the stage in which the hair grows in length. Also by stimulating the growth of new hair shafts.

The benefits of the action of these two biopeptides are:

  • Start of hair follicle growth.
  • Revitalization of the hair bulb cells.
  • Elongation of the terminal hair cycle, accelerating the growth of the hair shaft and lengthening the of growth stage (anagen).
  • Improvement of the length and volume of the terminal hair.
  • Increased density in scalp hair.

2. Action on the hair growth cycle

a) Octapeptide-11

Stimulates angiogenesis, or new blood vessel formation, by improving microcirculation and, consequently, improving vascularisation of the scalp treated.

In addition, it blocks the DHT expression or Dehydroepiandrosterone, a key molecule in the origin of androgenic alopecia.

b) Decapeptide-10 and octapeptide-2

These biopeptides stimulate the production of proteins in the follicular cells, facilitating the production of substances that provide the medium suitable for hair regeneration, to produce an increase in hyaluronic acid, keratin and fibronectin fibres synthesis.

They also activate the growth factor that induces the migration and proliferation of follicular cells to form the hair shaft, resulting in highly resistant keratin.

They improve the inter cellular junction of cells that make up the hair shaft, bringing more density and strength to the hair. They also repair damaged cells.

As a result of these stimulations, the following benefits occur:

  • The follicular root improves its nutrition and function.
  • Stops androgenic hair loss.
  • Improves the hair, providing greater thickness and resistance.
  • Improves the degree of apoptosis or cell activity loss by age.

3. Inhibiting hair loss or alopecia

a) Oligopeptide-54

This biopeptide silences the activity of the genes responsible for the androgenic hair loss by blocking the expression of the gene sensitive to DHT.

In addition, it stimulates the metabolism of melanocytes and their migration, improving the generation of follicular melanin and thus acting on the hair colour.

b) Oligopeptide-71

Degrades the IKB factor, a hair growth inhibiting factor and its subsequent fall causing component.

Promotes gene expression that activates the follicular cycle of hair growth.

Interact on specific receptors in the cell membrane of the hair follicle cells that are involved in the immune response to stimuli, stress and antigens.

The result of the action of these two biopeptides are:

  • Inhibition of androgenic alopecia.
  • Delay in the appearance of gray hairs.
  • Immune system activation.
  • Prevention of hair affectation in stress situations in or environmental factors.

4. Elasticity and hydration

The greater amount of hyaluronic acid present in the scalp induces an improvement in hydration and viscoelasticity in the cell matrix, which improves the metabolism of follicular fibroblasts and, therefore, the elasticity of the hair improved.

Depending on the type of alopecia or the degree of capillary ageing of each patient, our dermatologists can prescribe different combinations of treatments, all of them compatible each other.

Would you like to know whether Hair Filler is for you? Request a free informative consultation now with one of our expert physicians.

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